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found that NF-B activation correlates with the expression of substance P and transient receptor potential cation channel subfamily V member 1 (TRPV1) in IVD tissues and may be associated with the generation or maintenance of peripheral pain by regulating pain-related neuropeptides in patients with degenerative disc diseases

Furthermore, such diets increase BAs synthesis, which emulsifies and degrades the intestinal mucus layer, thereby elevating gut permeability (77)