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Oral melanotic macule* is a localized pigmented lesion associated with increased melanin pigmentation of the stratified squamous epithelium

On a mechanistic level, the Psychedelic Iatrogenic Structural Dissociation (PISD) hypothesis proposes that these substances may lower the defensive barriers between the part of the personality that handles daily life (the Apparently Normal Personality) and the part that holds traumatic memories (the Emotional Personality), leading to psychological destabilization, emotional dysregulation, and identity fragmentation in individuals with histories of trauma [117,118,119]

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