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Current typical histopathological changes in Alzheimers disease include A plaques and tau tangles, the accumulation of these proteins leads to neuroinflammation and normal dysfunction, leading to neuronal death (Ye et al., 2021)

It is usually a combination of factors that have accumulated over time, each one reducing mitochondrial output further until the patient crosses a threshold where normal functioning becomes impossible

coli BL21 cells were transformed with the plasmid containing Nb35 target gene and were grown in TB medium with 100 g/mL ampicillin, 1 M MgCl 2 , 2% (w/v) glucose at 37 C, 180 rpm for 3 h