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Fe 3+ is reduced to Fe 2+ by the six-transmembrane epithelial antigen of prostate 3, which is stored in the ferritin heavy chain (FTH) and ferritin light chain (FTL) ( 2+ is stored in ferritin (Fn) and becomes a part of the labile iron pool, which plays a dominant role in ferroptosis

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GPX4-overexpressing cells treated with CaOX exhibited stable GFP-GPX4 levels (Fig