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Although these agents are effective, they present several significant limitations: Safety concerns Biologics : Agents such as tumour necrosis factor- (TNF-) antagonists (e.g., infliximab, adalimumab, and etanercept) have revolutionised the treatment of rheumatoid arthritis and inflammatory bowel disease

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NRP1, widely expressed in olfactory and respiratory epithelia, is shown to enhance TMPRSS2-mediated viral cell entry 63

It causes a transient rise in systolic blood pressure ($+6$ mmHg) and a slight drop in heart rate that lasts about 12 hours