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The 2025 eClinicalMedicine meta-analysis (Tzang et al.) documented an average 5.63 kg regain in adults with obesity, with greater regain on semaglutide (8.21 kg) than liraglutide (4.29 kg) and with longer follow-up (7.31 kg beyond 26 weeks vs 2.51 kg)

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Pre- pregnancy GLP1RA use and impact on maternal health Although GLP1RA medications are not advised during pregnancy, use of GLP1RAs in the pre-pregnancy period has the potential for beneficial long-term effects by causing pre-pregnancy weight loss and allowing women to enter pregnancy metabolically healthier