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Traditionally, repertoire screening has been constrained by low-throughput methods that capture a small fraction of the BCRs found in vivo 5,6 , or by high-throughput sequencing strategies which decouple and recombine antibody chains, losing essential pairing optimizations occurring within the B cell germinal center 7,8

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Neuropharmacology 62 , 23202327 (2012)

Other authors, using co-culture of CD4 + T cells, demonstrated a similar effect on FLS, suggesting that the secretion of proinflammatory products of CD4 + T can promote glycolysis in FLS while downregulating OXPHOS 41