Nonetheless, this trend is consistent with broader societal shifts towards medicalised approaches to managing obesity [11, 41] and points to a need for healthcare systems and policymakers to decide how best to manage a continued surge in demand
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Thus, ARRB2 plays distinct roles in regulating GLP-1R and GIPR signaling, and this study highlights (1) its role in the physiological context and the possible functional consequences of its decreased expression in pathological situations such as diabetes and (2) the importance of assessing the signaling pathways engaged by the agonists (biased/dual) for therapeutic purposes..
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