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Glutathione is generally considered safe for most healthy adults

343 The additional unexpected observations from the GLP-1, GIP and GCGR tri-agonist studies 342,344 warrant further investigation, as these studies highlight the incomplete understanding of metabolic hormonal synergism, and that further elucidation of this will likely lead to more efficacious treatments for diseases such as T2D

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The choice of comparator - whether insulin, an insulin secretagogue, or an insulin-independent agent such as empagliflozin or metformin can significantly influence conclusions regarding the DR risk of a test agent