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The carnitine bound acylCoA residues within the mitochondria modulate intracellular concentrations of free CoA and are thought to play a key role in maintaining the acylCoA/CoA ratio, an important regulator of energy metabolism (Brass, 2003

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For the Sant Pau cohort, participants with DS with (dDS or prodromal AD (pDS)) and without AD-related cognitive impairment (aDS) were consecutively recruited at the Sant Pau Memory Unit, Barcelona, Spain from the Down Alzheimer Barcelona Neuroimaging Initiative (DABNI) study between May 2024 and November 2024

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