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They may arrange blood tests to evaluate: Inflammatory markers (ESR, CRP) to detect active inflammation Rheumatoid factor and anti-CCP antibodies if inflammatory arthritis is suspected Full blood count to assess haematological response to B12 treatment Thyroid function tests , as thyroid disorders commonly coexist with B12 deficiency Note that serum B12 levels are not typically measured to assess treatment adequacy once replacement therapy has begun, as they may not reliably reflect tissue stores

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PMID: 21475950 19

Yin Yang 1 (YY1), a highly conserved C2H2 zinc finger nuclear transcription factor that is overexpressed in M2 macrophages within PCa tissues, plays a crucial role in this process (Cho et al., 2018)