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Additional documentation may be required showing why the commercial product cannot be used

Even when tested for metabolic competency, the differences in the gene expression profiles compared to primary hepatocytes always raise concerns regarding the applicability of the investigated intracellular signaling mechanisms and the mode of cell death in humans

Researchers found that a high dose of melatonin could be used in clinical trials to decrease oxidative stress in ALS patients, but it does not appear to have a neuroprotective impact on the symptoms of the disease (Chen et al

However, this treatment may not suit those with a history of kidney disease, thyroid cancer, vision issues, or endocrine disorders