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[14] Small clinical trials indicate that maternal supplementation of 4,000 IU day or staggered 50,000 IU oral doses can safely maintain 25-hydroxyvitamin D above 30 ng mL without inducing hypercalcaemia, whereas single injections of 300,000 IU are reserved for severe malabsorption emergencies when benefits outweigh theoretical teratogenic risk

43 Another beneficial health impact of MSCs is enhanced mitochondrial function

Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration

Prolonged colonization of probiotics may disrupt gut microbiome structure, reduce beneficial commensals, and replace native microbes essential for immune balance (120, 121)