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The prolonged inflammatory state in chronic wounds also suppresses the function of key immune cells, including neutrophils and macrophages, by altering their cytokine profiles and impairing their ability to phagocytize and clear bacteria [45]

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In mammals, PRDX14 preferentially detoxify H 2 O 2 , whereas PRDX5 shows higher reactivity toward alkyl hydroperoxides and peroxynitrite, and PRDX6 reduces both H 2 O 2 and LOOHs