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In vitro , liraglutide dose-dependently downregulates pro-inflammatory mediators such as Mcp-1 and Cd38 in LPS-activated RAW264.7 macrophages, while simultaneously upregulating Erg-2, an M2-specific transcription factor (Yu et al., 2019)

In asking that question, Kevin started with a well known, yet confounding observation in the cancer immunology field: despite an inability to produce and release cytotoxic proteins, TILs express very high levels of cytotoxic transcripts (IFNG, Perforins, Granzymes)

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