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doi:10.1038/s42255-020-00327-x 21

DO has served as a speaker for Boehringer Ingelheim, Eli Lilly and Novo Nordisk, and served on advisory boards for Roche Diagnostics and Sanofi

The peptide also inhibits 5-alpha reductase, the enzyme that converts testosterone to DHT, potentially reducing follicular miniaturization

For example, in a 12-week randomized, double-blind, placebo-controlled trial (NCT01744236), 51 adults with T2DM, already receiving metformin and/or sulfonylureas, were assigned to liraglutide (1.8 mg), sitagliptin (100 mg), or placebo to assess the impact of GLP-1 receptor agonism and DPP-4 inhibition on gut microbiota composition