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Michael Lincoff, lead investigator of SELECT, stated: "Semaglutide reduced the risk of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke in adults with pre-existing cardiovascular disease and overweight or obesity" (NEJM, 2023)

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This could well account for the energy failure and widespread mitochondrial dysfunction previously observed in aspirin-treated MnSOD-deficient yeast cells, as indicated by a decreased respiratory rate, disrupted mitochondrial membrane potential, and release of cytochrome c 20

MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors