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Loss of function mutations in either Apo B-100 or MTTP result in the failure to produce VLDL and marked decreases in plasma triglyceride and cholesterol levels (familial hypobetalipoproteinemia or abetalipoproteinemia) (56)

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This development occurs as Novo Nordisk and Eli Lilly continue to defend against thousands of lawsuits claiming they failed to warn about other serious risks associated with GLP-1 drugs, including gastroparesis and vision loss