Limitations include relatively short treatment periods (6 weeks per arm), potential carryover effects despite washout, modest sample size limiting power for subgroup analyses and exclusion of newer agents (e.g., tapentadol) and long-term safety outcomes, which may restrict applicability to broader clinical practice
What theyre saying: There is a growing appreciation that the quality of weight loss is as important as the quantity of weight loss we believe that pemvidutide, if approved, could stand out as an attractive option for weight loss and weight maintenance. Altimmunes CMO Scott Harris The team effort The drugs: Regenerons trevogrumab and garetosmab are monoclonal antibodies
Mitchell KG, Farooqi A, Ludmir EB, Corsini EM, Zhang J, Sepesi B, Vaporciyan AA, Swisher SG , Heymach JV, Zhang J, Gomez DR, Antonoff MB
In August 2025, the FDA also approved Wegovy for the treatment of noncirrhotic MASH with moderate to advanced liver fibrosis 8