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This recommendation is based on animal studies in which semaglutide was associated with harmful effects on animal pregnancies and fetuses, such as fetal abnormalities, pregnancy losses, and growth changes in rats, rabbits, and monkeys

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Tirzepatide activates both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors the dual-receptor mechanism that produced the SURMOUNT trial results

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