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Bradley-Whitman and Lovell [135] reported that global levels of 5mC and 5hmC were significantly increased, whereas 2 intermediates (5-formylcytosine and 5-carboxylcytosine), in the demethylation steps, were significantly decreased

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While polymorphisms in UGT , CYP , SULT and GST genes are well established [22,23,8992] and might affect the response to acetaminophen, only polymorphisms in UGT genes have been widely studied in relation to APAP pharmacokinetics in humans [20,23,26,93]

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