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However, the cornerstone principle remains: long-term success with either medication hinges on continued use

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H3K27me3 is produced by the histone methyltransferase enhancer of Zeste homolog 2 (EZH2), the catalytic subunit of PRC2, and it is typically added to nucleosomes across upstream promoters and coding regions of PRC2-targeted genes to repress them (Xu et al., 2012)

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