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Post-mitotic cells, such as neurons, are particularly vulnerable to the accumulation of misfolded proteins during normal aging, concomitant with a decrease in proteasome activity

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First, NO may affect contractile function via its involvement at the neuromuscular junction (Kumar et al., 2022)

Although there isnt much research yet that directly studies the microbiome and RA fatigue, we do know that people with RA may have different gut microbes than their healthy counterparts 10 11