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Description

GSH is synthesized exclusively in the cytosol in two consecutive ATP-requiring steps, the first of which, and rate limiting, being -glutamylcysteine formation by glutamate-cysteine ligase (GCL)

Marklund et al., 2006)

Postischemic, systemic administration of polyamine-modified superoxide dismutase reduces hippocampal CA1 neurodegeneration in rat global cerebral ischemia