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Methods: 8wks old, male AJ and C57Bl/6J mice were fed ad libitum either a low-fat control diet (LFD: 13% saturated fat) or a Western-style high-fat, high-fructose diet (HFD: 42% saturated fat) for 12 weeks then fasted for 4h prior to sacrifice

GYY4137 attenuates LPS/ATP-induced mitochondrial dysfunctions by inhibiting the NF-kB signaling pathway We next sought to determine the mechanism by which GYY4137 attenuates LPS/ATP elicited mitochondrial dysfunctions

(PubMed) Montero D, Walther G, Stehouwer CD, Houben AJ, Beckman JA, Vinet A

Consistently, SFARI and TADA gene-set scoring across cell types demonstrated that the post-L-serine-treatment decrease in ASD risk-gene scores in CD4 T cells was maintained when utilizing the China/Asia-based healthy controls (Supplementary Fig