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Course Structure Seen in Trials and Labels Setting Acute stroke Daily volume 10-30 mL IV Daily amount (mg) ~2,152-6,456 mg Course length 10-21 days Repeat pattern Usually a single early course Setting Traumatic brain injury Daily volume 30-50 mL IV Daily amount (mg) ~6,456-10,760 mg Course length 10-21 days Repeat pattern Sometimes repeated Setting Dementia / cognitive Daily volume 5-30 mL IV or IM Daily amount (mg) ~1,076-6,456 mg Course length About 4 weeks Repeat pattern Cycled every few months Amounts assume the standard 215.2 mg/mL liquid

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