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Poster Session I - INTRACRANIAL HEMORRHAGE 02.00 - INTRACRANIAL HEMORRHAGE - 02.01 - INTRACEREBRAL HAEMORRHAGE P159 - ESOC25-2085 EFFICACY OF CLEVIDIPINE FOR BLOOD PRESSURE CONTROL AND VARIABILITY REDUCTION IN HYPERTENSIVE INTRACEREBRAL HEMORRHAGE: A PROSPECTIVE OBSERVATIONAL STUDY Joao Gomes 1 , Grace Conroy 1 , Catherine Hassett 1 , Yadi Li 1 , Justin Lindsay 2 , Christine Ahrens 1 1 Cleveland clinic, Cleveland, United States, 2 Wright State Boonshoft School of Medicine, Dayton, United States Background and Aims: Rapid blood pressure (BP) reduction within 60 minutes is associated with less hematoma expansion, whereas increased BP variability (BPV) correlates with poor outcomes
Sloppy Measurements: 'Eyeballing' the amount of water is a recipe for disaster
Studies show that 5-amino-1-methylquinolinium injection inhibits NNMT, normalizes nicotinamide metabolism, elevates NAD+, reduces oxidative stress in cells, suppresses apoptosis, preserves cell function, and promotes insulin secretion, supporting longterm glycemic control
Some preclinical work explores FOXO4-p53-targeting peptides against senescent cancer cells, and the developer has discussed cancer as a research interest, but there is no human evidence that FOXO4-DRI treats cancer
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