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For Wegovy (once-weekly semaglutide) , recommendations depend on several factors including: Your individual risk profile Whether you're in the dose escalation phase The presence of significant gastrointestinal symptoms Local endoscopy unit policies Many patients can safely continue Wegovy before colonoscopy under moderate sedation

[2] These medications work by mimicking the action of glucagon-like peptide-1, a naturally occurring hormone that regulates appetite and blood sugar levels