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Over time, many patients still benefit metabolically, but the feeling becomes less dramatic and more subtle

this number includes those who misused pharmaceutical synthetic opioids (United Nations Publication, 2020)

Treatment reinitiation Among those who discontinued a GLP-1 receptor agonist, the cumulative incidence of reinitiating treatment was 41.1% (95% CI 40.5, 41.7) at 1 year and 57.4% (95% CI 56.7, 58.1) at 3 years when using a grace period of 90 days in the definition of treatment discontinuation (Fig