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It functions as a soluble decoy receptor comprising the extracellular domain of the activin type IIB receptor (ActRIIB) fused to an IgG1-Fc region

Animal studies show oral BPC-157 produces measurable effects on gut healing and some systemic outcomes, but no human pharmacokinetic data confirms what fraction of the intact peptide survives first-pass digestion in people

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A 2022 editorial review by Sikiric and colleagues in World Journal of Gastroenterology synthesized prior rat work on major vessel occlusion, Pringle-maneuver ischemia-reperfusion, and Budd-Chiari syndrome, framing collateral-vessel recruitment as a proposed mechanism by which BPC-157 may compensate for occluded flow a narrative synthesis that does not itself report original effect sizes or p-values