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This group harbors mutations (generally point mutations) that activate catenin, a process that can be demonstrated by positive immunohistochemistry findings for the catenin marker58 or, alternatively, for LEF1 (the nuclear receptor of catenin).59 In the case of common nevus, positive findings for catenin are only observed in melanocytes close to the epidermis and adnexa, whereas in deep penetrating melanocytoma, catenin stains the cytoplasm of the tumor melanocytes uniformly and diffusely