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During the oxidation phase, accumulated ROS (such as hydrogen peroxide HO and superoxide anion O) in the cell can directly react with GSH in a non-enzymatic manner, or, under the catalysis of glutathione peroxidase (GPX), promote the oxidative coupling of two GSH molecules to form one molecule of GSSG, while releasing two protons (H) and two electrons (e)

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AMPK, a serine/threonine kinase, consists of three subunits , , and and is a cellular energy sensor activated in cellular states of energy deficiency, and turns off energy-consuming processes while inducing pathways providing energy [149]

Cancer cells derived EVs also contain several miRNAs and lncRNAs, and studies have extensively reported on the involvement of these miRNAs and lncRNAs in the transmission of drug resistance phenotypes and the extension of drug resistance to several drugs, such as DOX, gefitinib, erlotinib, trastuzumab, and cisplatin (311316)