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Trial protocols specify gentle swirling rather than shaking
Furthermore, to address concerns related to potential immortal time bias, we performed additional sensitivity analyses, varying the time window for tirzepatide initiation to assess whether different initiation periods influenced the results, and by resetting the index date to the HFpEF diagnosis date for both groups
Retatrutide is an investigational once-weekly injectable peptide that simultaneously activates GLP-1, GIP, and glucagon receptors, but it is not yet approved by the MHRA or EMA and remains experimental
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