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11/03/2025 Electronic publication Footnotes Conflict of interest: MEC has received speaking fees from Novo Nordisk

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CFR, which represents the maximal dilator response to an arteriolar vasodilator, is frequently applied but carries the disadvantage of representing the effects of macro- and microvascular disease ( Further studies are needed with adequate numbers of participants using highly accurate measures of CMF, such as positron emission tomography or cardiac magnetic resonance, to verify the hypothesis of GLP-1 and GLP-1 RAs affecting CMF