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The most noticeable difference in whole-brain activity signatures between GLP-1MK-801 and semaglutide was the significantly higher number of cFOS + cells in the nucleus accumbens in response to GLP-1MK-801 compared with semaglutide and vehicle treatment

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Adverse events and cognitive function were evaluated using the Common Terminology Criteria for Adverse Events (CTCAE) and the Hasegawa Dementia Rating Scale-revised (HDS-R)

Patients treated with Zepbound achieved an average weight loss of 20.2 percent of their body weight, compared to 13.7 percent for those on Wegovy