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GHK binds copper because of a specific combination of functional groups that together form a high-affinity copper-coordination site: the N-terminal amine donates one nitrogen ligand, the histidine imidazole donates a second nitrogen ligand, and the deprotonated amide nitrogen of the Gly-His peptide bond donates a third nitrogen ligand

TRPM2 is a non-selective cation channel with Ca 2+ permeability

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Other routes of administration such as taking vitamins orally are limited by many factors including time to absorption, suboptimal absorption rates due to digestive dysfunction, detoxification processed limiting dose available to the rest of the body, and often poor bioavailability of active ingredients found in common supplement brands