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Initial efforts should be directed at managing these life-threatening symptoms, and may involve ventilatory and pressor support as well as treatment of underlying infections

The liver is especially relevant because it produces and uses large amounts of SAM, manages homocysteine through both remethylation and transsulfuration, synthesizes glutathione and carries out methylation- dependent reactions

Method of Administration Glutathione can be administered orally, topically, or intravenously

J Alzheimers Dis 48:591595 Louwerse ES, Weverling GJ, Bossuyt PM, Meyjes FE, de Jong JM (1995) Randomized, double-blind, controlled trial of acetylcysteine in amyotrophic lateral sclerosis