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Specker BL, Black A, Allen L, et al

Artesunate is used as the treatment of choice for severe malaria by the World Health Organization (WHO) over quinine

Lifestyle modifications that may help include wearing loose, soft-textured clothing made from natural fibers, using silk or satin bedsheets that produce less friction, maintaining a consistent room temperature to avoid thermal triggers, practicing stress reduction techniques since psychological stress can amplify central sensitization, and optimizing sleep hygiene since poor sleep worsens pain perception

It also helps "recycle" other antioxidants like Vitamin C and Vitamin E, making them more effective