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& Davis, D

A network meta-analysis published recently confirmed this pattern, finding that retatrutide demonstrated greater absolute weight reduction compared to tirzepatide (retatrutide: MD -16.34 kg vs tirzepatide: MD -11.82 kg)

These range from FDA-approved medications, such as GLP-1 receptor agonists (Wegovy, Zepbound) for weight loss, to unregulated compounds with minimal or no human safety data