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Some patients and clinicians are exploring microdosing for inflammation rather than full weight-loss doses, but this approach is entirely unvalidated

Because insulin cannot be passively transported into the brain due to its high molecular weight of 5,800 Da (Hallschmid, 2021) and the efficiency of delivery to the brain by intranasal administration is low, CPPs are considered as the ideal potential vehicles (Kamei and Takeda-Morishita, 2015)

Moreover, the NTG and POAG patients in the validation study population also had a significant reduction in patients with stage 3 visual field loss (Fig