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In contrast, patients with early-stage steatosis or those embedded in a context of profound systemic insulin resistance may present a less amenable target for short-term LC monotherapy, as the driving pathophysiology extends beyond immediate fatty acid flux

818 Ferroptosis in renal ischemia-reperfusion injury The kidney is extremely sensitive to I/R injury, and the mismatch between oxygen supply and oxygen demand leads to decreased oxidative metabolism, resulting in progressive damage of renal tubular epithelial cells

Patients frequently report symptoms such as nausea, vomiting, diarrhea, and abdominal discomfort, which can affect daily routines and lead to early discontinuation in some cases

I challenge the nephrology community to step forward and meet this challenge