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From a molecular mechanism perspective, RIPK2-mediated signaling activates the NF-B and MAPK pathways, promoting the release of pro-inflammatory cytokines such as TNF-, IL-6, and IL-12/23, thereby driving the inflammatory response
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To identify the transcriptional adaptations underlying the metabolic changes induced by GSH depletion, we performed qRT-PCR to quantify the expression of key regulators of lipid and glucose metabolism, as well as fibrosis, in liver tissues from mice fed either a chow diet or HFD
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