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Metformin should be initiated unless (1) contraindications exist, (2) the A1C level indicates the need for insulin (at which time both insulin and metformin could be started), or (3) the A1C level is very close to goal (within 0.5% of goal) at the time of diagnosis and the patient is motivated to make appropriate lifestyle interventions
Available from: Aminian A, Vidal J, Salminen P, et al
These medications have been extensively studied in large-scale clinical trials and are licensed by the MHRA for specific indications including type 2 diabetes and, in some cases, weight management, as outlined in NICE guidance (NG28)
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