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If a significant part of this mechanism relies on re-absorption from bile that would be an issue due to lack of intrinsic factor breaking the "enterohepatic recirculation"

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The increased intracellular Ca 2+ causes the secretory insulin-containing granules to prime and fuse to the plasma membrane, leading to insulin exocytosis (246)

The influence of soil pH on the diversity, abundance and transcriptional activity of ammonia oxidizing archaea and bacteria