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Though many people using the patches swear by their efficacy, experts question the supposed science behind the viral supplements and point toward a potential placebo effect

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For experiments visualising axonal projections from brainstem PPG neurons PPG-YFP mice and PPG-Cre mice were crossed, and their YFP- and Cre-positive offspring ( n = 3) injected bilaterally with AAV2-Ef1a-DIO-tdTomato (0.25 l/injection