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Last reviewed: June 10, 2026 Last updated: June 10, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

Rosenstock J, Fras JP, Rodbard HW et al (2023) Tirzepatide vs insulin lispro added to basal insulin in type 2 diabetes: the SURPASS-6 randomized clinical trial

The medication mimics two digestive hormones (GLP-1 and GIP), resulting in lower blood sugar

This is partly a consequence of significant caloric restriction driven by reduced appetite, and partly a direct pharmacological effect