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While these findings provide preliminary evidence of the potential benefit of semaglutide in CUD in real-world populations, further preclinical studies are warranted to understand the underlying mechanism and randomized clinical trials are needed to support its use clinically for CUD

Author contributions All authors contributed to conception and design, analysis and interpretation of the evidence, drafting of the manuscript, finalization of the manuscript, and the decision to submit to publication

All above results demonstrated that mitophagy dysfunction may be a cause of cardiac hypertrophy induced by pressure overload, and semaglutide may mitigate pressure overload-induced left ventricular hypertrophy by improving mitophagy

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