To isolate the effect of GLP1 medication, the researchers compared people using GLP-1 medication with similar people who only used metformin (another diabetes medicine)
The best evidence for weight loss comes from a meta-analysis of 37 trials: a modest average reduction of about 1.2 kg (under 3 lbs), mostly in adults who are overweight

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They work by directly stimulating the pituitary gland to release LH and FSH, which in turn signal the testes to produce more testosterone