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Mechanistically, it inhibits glycolysis and mitochondrial hyperactivation in CD4 + T cells, thereby suppressing Th1/Th17 cell differentiation and promoting Treg cell expansion (221, 248)

For instance, identification of suicidal outcomes by means of ICD codes registered during routine clinical practice databases has been associated with a slight under-registration of cases, which may result in underestimation of the association between drug exposure and SIS outcomes [35], and studies validating suicidal classification have concluded that ICD codes have good positive predictive value but low specificity [36]

This dual-front approach significantly increases the pressure on brand companies: they must defend their patents on two simultaneous fronts with different procedural rules and different standards of proof [52]

Recently, NTZ has been repurposed to treat hyperlipidemia, hepatic steatosis (Li et al., 2022), as well as atherosclerosis (Ma et al., 2023)