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The change in body weight was 8.82% after 24 weeks of liraglutide treatment, whereas it was stable in the placebo group

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Orforglipron represents a potential paradigm shift as the first oral non-peptide GLP-1 agonist without fasting restrictions, and it demonstrated superiority over oral semaglutide in the head-to-head ACHIEVE-3 trial for both HbA1c and weight loss

Denniss SG, Haffner TD, Kroetsch JT, Davidson SR, Rush JW, Hughson RL: Effect of short-term lycopene supplementation and postprandial dyslipidemia on plasma antioxidants and biomarkers of endothelial health in young, healthy individuals